Search results for " N.I.H."
showing 10 items of 161 documents
Routing electric vehicles with a single recharge per route
2020
Networks : an international journal (2020). doi:10.1002/net.21964
K-nearest neighbor driving active contours to delineate biological tumor volumes
2019
Abstract An algorithm for tumor delineation in positron emission tomography (PET) is presented. Segmentation is achieved by a local active contour algorithm, integrated and optimized with the k-nearest neighbor (KNN) classification method, which takes advantage of the stratified k-fold cross-validation strategy. The proposed approach is evaluated considering the delineation of cancers located in different body districts (i.e. brain, head and neck, and lung), and considering different PET radioactive tracers. Data are pre-processed in order to be expressed in terms of standardized uptake value, the most widely used PET quantification index. The algorithm uses an initial, operator selected re…
Alignment Free Dissimilarities for Nucleosome Classification
2016
Epigenetic mechanisms such as nucleosome positioning, histone modifications and DNA methylation play an important role in the regulation of cell type-specific gene activities, yet how epigenetic patterns are established and maintained remains poorly understood. Recent studies have shown a role of DNA sequences in recruitment of epigenetic regulators. For this reason, the use of more suitable similarities or dissimilarity between DNA sequences could help in the context of epigenetic studies. In particular, alignment-free dissimilarities have already been successfully applied to identify distinct sequence features that are associated with epigenetic patterns and to predict epigenomic profiles…
Greedy randomized adaptive search procedure with exterior path relinking for differential dispersion minimization
2015
We propose several new hybrid heuristics for the differential dispersion problem, the best of which consists of a GRASP with sampled greedy construction with variable neighborhood search for local improvement. The heuristic maintains an elite set of high-quality solutions throughout the search. After a fixed number of GRASP iterations, exterior path relinking is applied between all pairs of elite set solutions and the best solution found is returned. Exterior path relinking, or path separation, a variant of the more common interior path relinking, is first applied in this paper. In interior path relinking, paths in the neighborhood solution space connecting good solutions are explored betwe…
An Information-Theoretic Framework to Measure the Dynamic Interaction between Neural Spike Trains
2021
Understanding the interaction patterns among simultaneous recordings of spike trains from multiple neuronal units is a key topic in neuroscience. However, an optimal approach of assessing these interactions has not been established, as existing methods either do not consider the inherent point process nature of spike trains or are based on parametric assumptions that may lead to wrong inferences if not met. This work presents a framework, grounded in the field of information dynamics, for the model-free, continuous-time estimation of both undirected (symmetric) and directed (causal) interactions between pairs of spike trains. The framework decomposes the overall information exchanged dynami…
Radio frequency fingerprinting for outdoor user equipment localization
2017
The recent advancements in cellular mobile technology and smart phone usage have opened opportunities for researchers and commercial companies to develop ubiquitous low cost localization systems. Radio frequency (RF) fingerprinting is a popular positioning technique which uses radio signal strength (RSS) values from already existing infrastructures to provide satisfactory user positioning accuracy in indoor and densely built outdoor urban areas where Global Navigation Satellite System (GNSS) signal is poor and hard to reach. However a major requirement for the RF fingerprinting to maintain good localization accuracy is the collection and updating of large training database. The Minimization…
Clustering statistics in cosmology
2002
The main tools in cosmology for comparing theoretical models with the observations of the galaxy distribution are statistical. We will review the applications of spatial statistics to the description of the large-scale structure of the universe. Special topics discussed in this talk will be: description of the galaxy samples, selection effects and biases, correlation functions, Fourier analysis, nearest neighbor statistics, Minkowski functionals and structure statistics. Special attention will be devoted to scaling laws and the use of the lacunarity measures in the description of the cosmic texture.
A one class KNN for signal identification: a biological case study
2009
The paper describes an application of a one class KNN to identify different signal patterns embedded in a noise structured background. The problem becomes harder whenever only one pattern is well-represented in the signal; in such cases, one class classifier techniques are more indicated. The classification phase is applied after a preprocessing phase based on a multi layer model (MLM) that provides preliminary signal segmentation in an interval feature space. The one class KNN has been tested on synthetic and real (Saccharomyces cerevisiae) microarray data in the specific problem of DNA nucleosome and linker regions identification. Results have shown, in both cases, a good recognition rate.
Entropy-Based Detection of Complexity and Nonlinearity in Short-Term Heart Period Variability under different Physiopathological States
2020
We compare different estimators of a popular en-tropy-based nonlinear dynamic measure, i.e. the conditional entropy (CE), as regards their ability to assess the complexity and nonlinearity of short-term heart rate variability (HRV). The CE is computed using binning, kernel and nearest neighbor entropy estimators in HRV time series measured from young, old and post-myocardial infarction patients studied at rest and during orthostatic stress. We find that the three estimators yield similar patterns of CE, but different patterns of nonlinear dynamics, across groups and conditions. These results suggest that the strategy for CE estimation is not crucial for the quantification of complexity, but…
Energy planning methodology of net-zero energy solar neighborhoods in the Mediterranean basin
2016
The article proposes a simplified methodology to optimize solar energy gains at district level in the Mediterranean area toward the achievement of the net-zero energy district target, to be applicable as well in similar hot climates. The approach includes a wide use of parametric analysis to explore the most impactful aspects of the design of solar net-zero energy districts: single unit shape, building mutual distances, road shape, building orientation, photovoltaics area availability to identify the optimal design solution. Thirty-two different district configurations are explored: results show that in the Mediterranean context, it is possible to reach the net-zero energy district target i…