Search results for " N.I.H."
showing 10 items of 161 documents
K-nearest neighbor driving active contours to delineate biological tumor volumes
2019
Abstract An algorithm for tumor delineation in positron emission tomography (PET) is presented. Segmentation is achieved by a local active contour algorithm, integrated and optimized with the k-nearest neighbor (KNN) classification method, which takes advantage of the stratified k-fold cross-validation strategy. The proposed approach is evaluated considering the delineation of cancers located in different body districts (i.e. brain, head and neck, and lung), and considering different PET radioactive tracers. Data are pre-processed in order to be expressed in terms of standardized uptake value, the most widely used PET quantification index. The algorithm uses an initial, operator selected re…
Iterated greedy with variable neighborhood search for a multiobjective waste collection problem
2020
Abstract In the last few years, the application of decision making to logistic problems has become crucial for public and private organizations. Efficient decisions clearly contribute to improve operational aspects such as cost reduction or service improvement. The particular case of waste collection service considered in this paper involves a set of economic, labor and environmental issues that translate into difficult operational problems. They pose a challenge to nowadays optimization technologies since they have multiple constraints and multiple objectives that may be in conflict. We therefore need to resort to multiobjective approaches to model and solve this problem, providing efficie…
Improving the performance of embedded systems with variable neighborhood search
2017
Graphical abstractDisplay Omitted Embedded systems have become an essential part of our lives, mainly due to the evolution of technology in the last years. However, the power consumption of these devices is one of their most important drawbacks. It has been proven that an efficient use of the memory of the device also improves its energy performance. This work efficiently solves the dynamic memory allocation problem, which can be formally defined as follows: given a program that has to be executed by a circuit, the objective is to fit that program in memory in such a way that the computing time required to execute it is minimized. In this work, we propose a parallel variable neighborhood se…
Alignment Free Dissimilarities for Nucleosome Classification
2016
Epigenetic mechanisms such as nucleosome positioning, histone modifications and DNA methylation play an important role in the regulation of cell type-specific gene activities, yet how epigenetic patterns are established and maintained remains poorly understood. Recent studies have shown a role of DNA sequences in recruitment of epigenetic regulators. For this reason, the use of more suitable similarities or dissimilarity between DNA sequences could help in the context of epigenetic studies. In particular, alignment-free dissimilarities have already been successfully applied to identify distinct sequence features that are associated with epigenetic patterns and to predict epigenomic profiles…
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
2016
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation o…
Guidelines for the use of flow cytometry and cell sorting in immunological studies
2017
The marriage between immunology and cytometry is one of the most stable and productive in the recent history of science. A rapid search in PubMed shows that, as of July 2017, using “flow cytometry immunology” as a search term yields more than 68 000 articles, the first of which, interestingly, is not about lymphocytes. It might be stated that, after a short engagement, the exchange of the wedding rings between immunology and cytometry officially occurred when the idea to link fluorochromes to monoclonal antibodies came about. After this, recognizing different types of cells became relatively easy and feasible not only by using a simple fluorescence microscope, but also by a complex and some…
Maristem stem cells of marine/aquatic invertebrates: from basic research to innovative applications
2018
The “stem cells” discipline represents one of the most dynamic areas in biomedicine. While adult marine/aquatic invertebrate stem cell (MISC) biology is of prime research and medical interest, studies on stem cells from organisms outside the classical vertebrate (e.g., human, mouse, and zebrafish) and invertebrate (e.g., Drosophila, Caenorhabditis) models have not been pursued vigorously. Marine/aquatic invertebrates constitute the largest biodiversity and the widest phylogenetic radiation on Earth, from morphologically simple organisms (e.g., sponges, cnidarians), to the more complex mollusks, crustaceans, echinoderms, and protochordates. These organisms contain a kaleidoscope of MISC-type…
Being a good neighbour: developing intercultural understanding through critical dialogue between an Australian and Finnish cross-case study
2020
Language educators in Australia and Finland are expected to foster intercultural understanding within foreign language education. This paper presents findings from a qualitative case study focusing on theoretical and practical intercultural understanding in secondary school language education. The data for this study includes lesson observations as well as student and teachers interviews collected in two secondary schools in Australia and Finland. The findings demonstrate the complex resources teachers and students draw on to develop and share intercultural understanding. The discussion addresses the value of different perspectives and the need for a new metaphor to conceptualise intercultu…
Adaptive Large Neighborhood Search with a Constant-Time Feasibility Test for the Dial-a-Ride Problem
2019
In the dial-a-ride problem, user-specified transport requests from origin to destination points have to be served by a fleet of homogeneous vehicles. The problem variant we consider aims at finding a set of minimum-cost routes satisfying constraints on vehicle capacity, time windows, maximum route duration, and maximum user ride times. We propose an adaptive large neighborhood search (ALNS) for its solution. The key novelty of the approach is an exact amortized constant-time algorithm for evaluating the feasibility of request insertions in the repair steps of the ALNS. In addition, we use two optional improvement techniques: a local-search-based intraroute improvement of routes of promisin…
Eiropas Savienības un Azerbaidžānas attiecības Eiropas kaimiņattiecību politikas kontekstā
2019
Šajā pētījumā tiek izvērtētas Azerbaidžānas un Eiropas Savienības (ES) divpusējās attiecības. Pētījuma autore analizējusi šo attiecību daudzpusību, kas izpaužas tādās sfērās kā ekonomika, enerģētika, tirdzniecība un politika. Šis pētījums arī uzsver virkni ES pieņemtu politiku, kas saistītas ar Azerbaidžānu, tostarp Eiropas kaimiņattiecību politiku un Austrumu Partnerības programmu. Autore izmantojusi arī empīrisko analīzi, lai izvērtētu cik ciešas ir Azerbaidžānas un ES ekonomiskās un tirdzniecības saites. Ar teorētisku un analītisku pētījumu vērtēta Eiropas Kaimiņattiecību politikas rīcības plāna īstenošana Azerbaidžānā. Autore salīdzinājusi galvenos ekonomiskos statistikas datus starp Ei…